Oxidative lipidomics
نویسندگان
چکیده
منابع مشابه
Myocardial lipidomics. Developments in myocardial nuclear lipidomics.
The development of electrospray ionization mass spectrometry has been critical for the analyses of lipidomes from subcellular organelles. The myocardial nuclear lipidome likely has a key role in the molecular regulation of gene expression. In fact, recent studies have suggested that specific phospholipid classes bind and regulate specific transcription factors. The dynamic regulation of the myo...
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Lipids are recognized as extremely diversified molecules, with nearly 10 different structures of lipids currently being stored in the most comprehensive lipid structure database (LIPID MAPS, http://www.lipidmaps.org). The complexity is confounded by the fact that the absolute quantity of individual molecular lipids can differ among lipid species up to several million-fold depending on the matri...
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SIGNIFICANCE Oxidized phospholipids are now well recognized as markers of biological oxidative stress and bioactive molecules with both pro-inflammatory and anti-inflammatory effects. While analytical methods continue to be developed for studies of generic lipid oxidation, mass spectrometry (MS) has underpinned the advances in knowledge of specific oxidized phospholipids by allowing their ident...
متن کاملOxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation.
Reactive oxygen species have been shown to play a significant role in hyperoxia-induced acute lung injury, in part, by inducing apoptosis of pulmonary endothelium. However, the signaling roles of phospholipid oxidation products in pulmonary endothelial apoptosis have not been studied. Using an oxidative lipidomics approach, we identified individual molecular species of phospholipids involved in...
متن کاملLOBSTAHS: An Adduct-Based Lipidomics Strategy for Discovery and Identification of Oxidative Stress Biomarkers.
Discovery and identification of molecular biomarkers in large LC/MS data sets requires significant automation without loss of accuracy in the compound screening and annotation process. Here, we describe a lipidomics workflow and open-source software package for high-throughput annotation and putative identification of lipid, oxidized lipid, and oxylipin biomarkers in high-mass-accuracy HPLC-MS ...
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ژورنال
عنوان ژورنال: Integrative Molecular Medicine
سال: 2018
ISSN: 2056-6360
DOI: 10.15761/imm.1000351